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Prenatal exposure for endocrine disrupting chemicals and outcomes of allergic diseases in human offspring

Document type: Projects: Funding approved
Document language: English
Uploaded By: Karl Gauffin (kgauf)
Date Uploaded: 2012/02/03 11:19:03.342 GMT+1
URL to a webpage or document based online: http://

Basic Information

Authors: Carl-Gustaf Bornehag
Funding source project: Swedish Research Council

During the last decades more than 100 000 new chemicals have been introduced to the environment. Of specific concern are compounds that are suspected to be endocrine disrupting chemicals (EDCs). The presence of EDCs in our environment raises concern because harmful effects have been observed in animals and there are suspicions that such exposure may affect human health. One important observation is that during the same period of time as EDCs have been introduced there has been a dramatic increase in asthma and allergy as well as other chronic diseases/disorders among children. One specific concern is foetal exposure coming from an increasing understanding that the foetus is extremely sensitive to hormone-mimicking exposure during certain critical phases of development. Based on epidemiological and experimental data there have recently been raised hypotheses that EDC exposure during early life may determining the outcome of allergic diseases in children. We therefore suggest using data in the on-going SELMA birth cohort study in order to meet the following aims: - Examine the importance of prenatal exposure for selected EDCs (measured as biomarkers for phthalates, bisphenol A, and 4-nonylfphenol in pregnant women?s urine) for allergic outcomes in the offspring during their first 3 years of life. - Investigate to what extent human uptake is related to exposure of selected EDCs in indoor dust. - Determine the most important sources for selected EDCs in indoor dust.

Riche Classification

Child Related Topics: Children’s homes ,
Health issues, determinants and measures: Allergy , Asthma , House dust mite allergy , Analytical, Diagnostic and therapeutic Techniques and Equipment , Diagnosis and therapy , Mental functions , Metabolic and Endocrine ,