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Explaining differences in birth size and adiposity between Pakistani and white babies.

Document type: Projects: In progress/completed
Document language: English
Uploaded By: Allan Colver (allancolver)
Date Uploaded: 2012/01/12 14:00:39.025 GMT+1
URL to a webpage or document based online: http://www.mrc.ac.uk/ResearchPortfolio/Grant/Record.htm?GrantRef=G0601712&CaseId=9511

Basic Information

Authors: Mrs J West, University of Leeds
Published on Date: 2007
Funding source project: Medical Research Council (MRC)
Abstract:

Background
Low birth weight is recognised as an important predictor of child and adult health. In the UK there are marked differences in birth size between babies of south Asian origin and white babies. Babies born to south Asian families are generally lighter and it is unclear whether this difference reduces in second and third generations of UK south Asians. As adults south Asians have the highest mortality rate from coronary heart disease with much of the excess risk believed to be due to an increased risk of type 2 diabetes. For a given body mass index they are more centrally obese and are more likely to be insulin resistant. This has led to the suggestion that south Asians have a specific fat-thin insulin resistant phenotype. However relatively little is known about the fat-thin phenotype in south Asians living in the UK.
Aims
This proposal will take advantage of a newly funded bi-ethnic birth cohort study located in Bradford to examine differences in birth size and adiposity between 2500 white babies and 2500 Pakistani babies. Specifically this proposal aims to determine whether differences in birth anthropometry have reduced with subsequent generation immigrants, whether differences in size between white and Pakistani babies are detectable by ultrasound scan in the first, second and third trimester of pregnancy and whether there is evidence for the existence of the 'fat-thin insulin resistant phenotype' at birth among Pakistani babies in comparison to white babies.
Design
Collection and analysis of data from a birth cohort study
Methods
This proposal will collect and analyse data from the Born in Bradford study, a new birth cohort study based at Bradford Teaching Hospitals NHS Trust which has secured funding and is due to begin recruiting participants in November 2006.This proposal will use data from 5000 mothers, fathers and their offspring (2500 white and 2500 Pakistani) who will be recruited in the first 18 months of the project. Data collection will include ultrasound assessment of fetal growth, birth anthropometry, cord blood samples, socio-economic status, lifestyle and country of origin data. Statistical analysis will apply Students t-tests and multivariable linear regression models to make comparisons between Pakistani and white babies. Power calculation: There will be 85-90% (or greater) power, at the 5% alpha level, to test all of the hypotheses proposed.


Riche Classification

Taxonomy:
Demography: All , Gestation: , Conception ,
Population Groups: Socio-economic status , Ethnic minority groups ,
Child Related Topics: Health care involving children ,
Health issues, determinants and measures: Family planning; Reproductive Health and Childbirth , Pregnancy ,
Languages and Geographical Perspective: United Kingdom , English ,
Study type / scale / state of progress / setting: Longitudinal study - cohort, trend, panel , Health care facility , Province or Region , Ongoing ,