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Association between air pollution in Scania and type 1 diabetes

Document type: Projects: Funding approved
Document language: English
Uploaded By: Karl Gauffin (kgauf)
Date Uploaded: 2012/02/03 11:51:16.404 GMT+1
URL to a webpage or document based online: http://

Basic Information

Authors: Lars Rylander
Funding source project: Swedish Research Council

The incidence of type 1 diabetes (T1D) has during recent years increased dramatically, which reasonably not is, more than partially, due to risk genes. Air pollutants have been suggested as a risk factor for developing T1D. The current project will, within a well-defined study base, perform nested case-control studies which aim to investigate whether increased exposure to air pollution in Scania affect the risk for developing autoantibodies to insulin (IAA) and T1D. The study base (DIPIS project=Diabetes Prediction In Scania) includes detailed information for about 35 000 children born in Scania during the period 2001-2004. For each case (children who has developed IAA, n=140; T1D, n=100) five control children will be selected. The measures of exposure for the mother/child will be obtained by: 1) dispersion models based on data from a large Emission data base (NO2 and NOX), 2) distance to road with specific traffic intensity, and 3) measured data from monitoring stations (particles, PM2.5 [fraction of particles <2.5um] and PM10, and NOX, O3 and SO2). Of importance for the study is the use of the GIS tool (Geographical Information System). Individuals are positioned according to the centre coordinate of the real estate where they live. Accordingly, the exposures on an individual level can be estimated, by linkage in the GIS tool. The study will evaluate the importance of exposures during different time windows during pregnancy as well as exposure after birth.

Riche Classification

Demography: Young (pre-school ) child (including those attending Kindergarten / playgroup / child care) ,
Health issues, determinants and measures: Environment , Air pollution / Pollution and care of the environment , Morbidity , Diabetes ,
Languages and Geographical Perspective: Sweden ,
Study type / scale / state of progress / setting: Case/control study , Province or Region ,